Suphan Buri is an ancient city with archaeological evidence suggesting human habitation dating back 3,500 to 3,800 years, spanning the Neolithic, Bronze, and Iron Ages. Originally known as “Dvaravati Sri Suphannaphum” or “Phanthum Buri,” the city has witnessed a succession of cultural influences from the Suvarnabhumi, Funan, Amaravati, Dvaravati, and Srivijaya civilizations. Located along the Tha Chin River, the city's strategic placement established it as a prominent trade and defense hub.

During King U-Thong’s reign, the city was renamed "Suphan Buri" after being previously referred to as "Song Phan Buri" (City of Two Thousand) and "U-Thong." As a frontline city during the Ayutthaya era, Suphan Buri was crucial in resisting invasions, including the renowned elephant duel in which King Naresuan triumphed over the Burmese Crown Prince at Don Chedi—a victory celebrated annually to honor this historic event.

Suphan Buri is also known as the setting for the Thai literary classic "Khun Chang Khun Phaen," with numerous landmarks still recognizable today, such as Wat Pa Lelai and Wat Khae.